Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
●"Man shoots off his own penis taking selfies with gun"
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
On the a monthly basis prices fell by an average 0.5 per cent.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
About 40 per cent of entrepreneurs did not seek any help when securing finance. Half of these raised equity purely from their own savings and/or family and friends compared with only 40 per cent of those who sought help from the school or alumni network.
A person walks through snow Tuesday in Belington, West Virginia. Superstorm Sandy buried parts of West Virginia under more than a foot of snow on Tuesday.
If it isn't appropriate to interrupt, make a quick note of your question so you don't forget, and ask later.
Trends and targets in antiviral phototherapy
The Pelicans have struggle to attract and keep free agents, they must retain Jrue Holiday this summer, Cousins is from nearby Alabama and enjoys a close friendship with Anthony Davis, and years of disappointing and injury-plagued seasons put the franchise in a position where it seemed to be teetering on perennial also-ran status.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Roth, 60, is a professor at Harvard University in Boston. Shapley, 89, is a professor emeritus at University of California Los Angeles.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
In fact, academic research suggests that other economic and social transformations unfolding at the same time have led many people to anchor themselves more fully in their whiteness — even as whiteness itself has lost currency.
The prize sold for a winning bid of $950,000 at auction, and an additional buyer's commission brought the final sale price to $1.16 million.
ACE2 as a potential therapeutic target for pandemic COVID-19
12. Zoho CRM
You might think that our love of lists could be pinned on the Ten Commandments, but Umberto Eco says otherwise. “The list is the origin of the culture,” he once said on a subject he knows well, having written a book titled “The Infinity of Lists.” And culture wants “to make infinity comprehensible” and “to create order — not always, but often,” hence Homer’s catalogs in “The Iliad” and the roll call of never-completed household chores on my fridge. “We like lists because we don’t want to die,” Mr. Eco also said, which is the best explanation of the listicle that I’ve yet read.
Diagnostic technologies for COVID-19: a review
Sohmers所推出的这个产品，可谓将高速运算能力和低能耗集为一体。Sohmers表示：“除了电子工程师外，我认为我还是一位创业者。我相信，我所作的工作，将会对整个世界产生重要的影响。”Sohmers在几年前从高中辍学，加入了Peter Thiel创立的创业加速器20 Under 20 Thiel Fellowship。2011年，在其他同龄人都在准备考大学的时候，Sohmers开始学习编程。他获得了10万美元的种子资金，并且跟随硅谷中一些著名的技术人才进行学习。Sohmers曾在麻省理工学院研究实验室进行工作和学习，研究从增强现实眼镜到激光通信系统的任何东西。也是在那里，他见到了REX的另一位联合创始人Kurt Keville。但是在他正式进入麻省理工学院研究室之前，他的父母似乎并不太支持他放弃学业。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
“只要总体市场仍然相对积极，只要交易继续执行良好，我们继续预期今年余下时间会保持健康的交易量，”高盛(Goldman Sachs)美洲股票资本市场主管戴维?路德维格(David Ludwig)表示。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
But that idea did not bring Brexit to the UK or Mr Trump to Washington.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
"The autonomous region has invested 4 billion yuan (around 600 million US dollars) to promote industries with local features in poor areas, and relocated 77,000 poor people last year," said Lu Huadong, deputy director with the office.
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
INDOORS: The two-story house, of brick and stucco with a ceramic tile roof, was designed by Dorr & Dorr, completed in 1916 and renovated over the last 15 years. The style is part Prairie, part Arts and Crafts, employing clean lines, open space, elegant woodwork and colored glass. Renovations were done by Joseph Metzler of Sala Architects in Minneapolis.
Do your homework. Read the assigned pages, and then some. Plug your topic into the Internet, grab another book at the library, and see what else you can learn about the subject.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The prize sold for a winning bid of $950,000 at auction, and an additional buyer's commission brought the final sale price to $1.16 million.
The paperpot transplanter allows a single person to transplant 264 plants covering over 85ft in just minutes. What used to take hours, now takes minutes. Allowing you to spend less time transplanting crops, and more time doing other things like farm improvements, marketing, sales, or just taking some time off.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
“Even though I’m an engineer and an analytical person at heart, the most important decisions I’ve ever made had nothing to do with any of that,” he told an interviewer at Duke University, where he studied for an MBA, last year. “They were always based on intuition.”
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Whatever happened to ‘Never complain; never explain' – the unofficial motto of the House of Windsor?
《傲骨贤妻》(The Good Wife)：艾丽西娅(Alicia)的秘密暧昧对象威尔（Will，乔希·查尔斯[Josh Charles]饰）在第五季末死去，CBS频道的这部性感法庭剧似乎要完蛋了，但是第六季却似乎充满了疯狂的能量——艾丽西娅初露头角的政治竞选、新旧公司的权力之争、合伙人卡里(Cary)的棘手法律事务。艾丽西娅不再那么完美，《傲骨贤妻》因此更好看了。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
3.Pay no attention to those bow-tied etiquette experts you sometimes see on CNN International, telling you how to behave while in Britain. These people are generally of dubious provenance, normally live in California and tend to peddle advice that is either irrelevant or out of date. For example, they will often say that Britons love queuing and are so fond of apologising that they will often say "sorry" even when something isn't their fault. In reality, Britons are just as likely to jump to the front of a queue and then punch the person behind them for coughing. It all depends on how muggy it is.
4) I often feel inhibited in social interactions 0 1 2 3 4
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Also important to EMBA entrepreneurs was the support of their school and alumni network. About three-quarters of entrepreneurs thought that both the school and their alumni network were helpful or very helpful when setting up their company. “Alumni support was key to getting the idea vetted and getting the right contacts needed for the business”, said one.
Inhibition of SARS coronavirus helicase by bismuth complexes
A vibrant ETF market would depend on the evolution of fee-based distribution networks. Mark Talbot, managing director of Asia-Pacific at Fidelity International, says the distribution infrastructure is holding back retail demand.
This includes ‘qwerty,’ in fourth place, ‘admin,’ in 11th, and ‘login’, in 14th.
Despite relatively low comparative competition earnings and salary, the pair were the two highest earners in regards to endorsement deals last year, with 17-time Grand Slam champion Federer earning pound 41 million.
CONTACT: Staci Donegan and Peter Westley, Celia Dunn Sotheby’s International Realty, (912) 247-2052 / (912) 660-5169; celiadunnsir.com
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
After all, during the last round of collections, the most striking pieces — from Louis Vuitton, Dior, Proenza Schouler, Narciso Rodriguez — had a streamlined momentum that wasn’t dragged down by any decade-related reference, or identity. They were clothes that went striding into the future, freed from the weight of the past.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Grains have fallen about 3 per cent.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
? The transport infrastructure in New York City has been dealt a huge blow. Many of the city's subway tunnels are flooded.
Sorry, folks, but if you're an investor hoping America's political internecine wars will improve in the near future, just don't invest. The war between Congress with it's abysmal 10% approval rating and the president, the war between the Dems, GOP and the tea party, is going to get even worse, upsetting markets and the economy even more.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
7. Build a reputation.
You see all kinds of grisly, hairy characters on the Tube but few commuters would've expected to see a pack of pandas on the platform.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
最佳综艺小品：帕顿?奥斯瓦特(Patton Oswalt)，《帕顿?奥斯瓦特：为掌声而鸣》(Patton Oswalt: Talking for Clapping)
They need more talent. Full stop. The best avenue for attracting talent for them has always been the draft.
As computer programming is being hailed as the untapped opportunity in the American economy, New York Code and Design Academy is making it easier to speak code. By 2020 there will be 1.5 million computer science jobs with only 400, 000 computer science graduates. Moreover, computer science jobs are growing at twice the national average as other positions. But what if you didn’t graduate with a computer science degree, and have no plans to go back to college? New York Code and Design Academy is making it easier to learn web design and development by offering both night programs and intensive workshops — where it’s not uncommon for someone to walk out of the program having built a new website or setting sights on a new tech-based position at work. From where Founder Jeremy Snepar sits, you can’t afford to not know how to code in today’s digital economy. He sees coding as a technical skill that can and should be easier to learn, and New York Code and Design Academy is filling an important gap for anyone who’s ever said “if only I knew how to code.”
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
《患难与共》(Togetherness)，HBO，1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人（《都市女孩》[Girls]第四季第一集将在同一天晚上播出），还有快到30岁的旧金山男同性恋（《寻》[Looking]也在当天开播第二季）。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass)，兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻，和杜普拉斯最好的朋友（史蒂夫·齐西斯[Steve Zissis]饰演）与林斯基的姊妹（阿曼达·皮特[Amanda Peet]饰）合住一栋房子。
Prices at China's factory gates fell for a 34th consecutive month in December, pushed down by falling energy and commodity prices.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
ICBC said net profits increased 0.5 per cent for the year to December 31 2015 — the smallest increase since it listed. Returns on average total assets declined 0.1 percentage points to 1.30 per cent.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
In contrast, the nation witnessed a tumbling trend for minivans, whose volume totaled 71,300 units, a 31 percent drop year-on-year.
Liu Fei was also a half-brother of the Emperor Wu of Han who ruled from 141BC to 97BC.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
It's lightweight and rolls up easily for travel.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
"The longer people sit out of the job market, the harder it's going to be for them to re-enter," Frederickson says.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
"Students are not suited for starting businesses on their own," said Zhang, adding that vocational students are more eager to start businesses than university undergraduates.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
In interviews, everyone works well with others, and everyone learns quickly. Please tell me something else.
Even if Asian countries introduced regulation similar to that of thriving ETF markets elsewhere in the world, there are other hurdles. Mr Montanari says, for example, that most products presented to Asian investors relate to equities in their domestic market so the ETFs are not being used to give investors local exposure to foreign markets.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
伊法斯夫拉腾以英国独立党(U.K. Independence Party)为例，它的官方平台力主脱欧，但是面向选民的宣传中又强调移民对经济与文化的影响，她说这是一种混合了务实与民粹的论调。
4. The 2012 Ig Nobel Neuroscience Prize
A modular microarray imaging system for highly specific COVID-19 antibody testing
GM is addicted to hefty sales incentives to move the cars and new CEO Ed Whitacre knows it. In 2010, he will slash incentives and end up abandoning GM's 20% U.S. market share target to find profitability. The search will prove elusive.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
The state-sponsored purchasing managers' index fell from 50.8 in October to 50.3 in November, the lowest reading since March. Any level above 50 indicates expansion.
Wishing you all the blessings of a beautiful season.愿你拥有美丽的新年所有的祝福。
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
乔布斯在苹果全球研发者大会上手持iPhone 4 ，2010年6月7日，旧金山
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
'I was blown away by him,' Kushner recalls. 'The first time I interacted with him was at News Corp, when he was meeting with Murdoch, and I was looped in to provide perspective. Nick described the vision of what he was trying to accomplish. And he was providing insight to Rupert.' D'Aloisio's stage presence, coupled with the deep-pocketed credibility brought by Li, attracted a large group of benefactors to Summly, including Ashton Kutcher, Yoko Ono and Stephen Fry.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
CONTACT: Debbie McNally, Lakes Sotheby’s International Realty, (612) 388-1790; debbiemcnally.com
In addition, the top-ranking cities typically performed poorly in costs and culture and lifestyle. China's "cities of opportunity" continue to face challenges when it comes to building cities that satisfy the needs of the populace and provide a high quality of life.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
The first drone can be traced back to 1916 when British inventor Archibald Low designed and flew the first unmanned radio-controlled vehicle. The drone was made to counterattack German Zeppelin airships, and it also carried out ground attacks during World War I. It was made with wood and tin, its wings taken from the lower wing of another biplane. Overall, the drone was somewhat unsuccessful because the noise from its engine interfered with its radio. The Sopwith Aircraft Company also tried making a drone in 1916. They placed the radio equipment at the tail so that the engine would not interfere with its signal, but their drone never flew as it was damaged in an accident on the ground. Low would try flying his drone again in 1917 when he flew it in front of some senior military officers. It was launched from the back of a lorry and flew for some time before crashing due to engine failure, almost killing the military officers present.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
In total, Chinese mainland has 54 institutions in the listing of top 300 universities in Asia.
On our increasingly human-dominated planet we can still learn much from the lives of other species. The discovery this year that the Greenland shark lives for 400 years, making it the longest-living vertebrate, puts our hectic lives into perspective.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Andrew Hill is management editor
I am so excited to be hosting the Oscars for the second time. You know what they say - the third time's the charm.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
8. Flats are allowed on the red carpet – or are they?
Length-scale dependence of protein hydration-shell density
Other high points for the school include being first for alumni international mobility, second for international experience and third for job placement.
The fundamentals of the Chinese economy remain sound, the capital adequacy ratio and provision coverage of commercial bans remain high, and we have many financial tools and instruments that can be used. We have the confidence, the ability, and the means to forestall systemic risks.
Executives from PwC immediately realized there was a problem, but they were too late to rectify the mistake as Dunaway read out the name La La Land from a card that was meant to be for the Best Actress award, which Emma Stone won for her role in the film earlier in the night.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Sonneborn says he's been dismayed not only by what he sees as Trump's troubling decisions and juvenile moments but also by the president's response after a counterprotester was killed during the August white nationalist rally in Charlottesville, Virginia — which is what cemented Sonneborn's decision to seek office.
A schoolgirl aged 11 has been honoured as "America's top young scientist" for inventing a quick, low-cost test to detect lead-contaminated water.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
据报道，霍莉·亨特（Holly Hunter）因出演《钢琴课》（The Piano）获最佳女主角奖，她的小金人放在科恩兄弟纽约的办公室中，它旁边还有因出演《冰血暴》（Fargo）而获得的奖杯。
For starters, breaches like that of Bitstamp and the much larger (valued at about $400 million at the time) 2011 hack of the exchange Mt. Gox are often misconstrued as security issues with the currency itself. But they are only signs of flaws in those particular exchanges and not a sign of an issue with the underlying technology. And it is the underlying technology behind bitcoin that most excites. As we wrote in the “Shape the Future” package of our January 2015 issue, most of the vocal enthusiasts so bullish on bitcoin—from big-name entrepreneurs like Marc Andreessen to the developers and miners who spend their days refreshing the bitcoin Reddit page—are more interested in the applications that can be built on bitcoin’s “block chain,” the currency’s foundational backbone, than they are in bitcoin as a monetary system. The block chain allows the secure exchange of any form of value between two entities.
What the government should do is to send a resounding message of “yes” to the all law-abiding market entities, to flash the green light of going ahead to the hardworking entrepreneurs and innovators, and to seriously deal with all violations of laws and regulations by showing them a resolutely a “yellow card” of stern warning, or even a “red card” to send them out of the market.
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May the glow of New Year candle fill your heart with peace and pleasure and make your New Year bright.