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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

目前已经得到证实的是,胡歌将会加盟该电影,继续出演主角“李逍遥”,而女主角的扮演者暂时还未透露。
Schools relied on a wide range of technologies to ensure lively interactive delivery of their programmes including virtual classrooms, live sessions and multimedia teaching materials. Alumni were asked to rate delivery as well as indicate how effective online exams were. Results were encouraging. Schools appear to be getting better at online delivery. Every aspect of online delivery was rated higher than it had been in previous years, showing a greater level of satisfaction.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

The next biggest provincial provinces were Jiangsu, Shandong, Zhejiang, Henan and Sichuan, finishing in the same position as 2015.
Jumping all in is rarely ever successful. There are success stories about people who invested everything once and came out winners after six months or a couple years, but those are rare. Risk management is an essential factor in any startup, and balance is vital. You can absorb losses more easily if you take smaller risks in the beginning. Those will provide essential and productive lessons.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

韩云平表示,去年全国的质量监督部门共提交了36000起和违反质量标准有关的案件,涉及金额达23亿人民币(约合3.33亿美元)的货物。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

It’s sometimes one of the scariest words in the English language, but it’s a word you should be prepared to say when opportunities arise in your career: Yes.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 买房不可忽视的参数
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

……带着狗来面试。
Technology and telecoms are on the up as are some fast food companies, including Starbucks, which BrandZ puts in this category, and McDonald's, whose brand value is risen by nine per cent even though its ranking is unchanged.
The current El , a naturally recurring phenomenon that warms the Pacific Ocean, was probably only responsible for about 10 per cent of 2015’s record-breaking temperatures, he added.
“An interviewer walked inta closet instead of the meeting room.”

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

China's pension insurance balance of urban employees and urban and rural residents added up to four trillion, according to the Annual Report on Social Security Development 2015.
胡润估计,中国内地目前有594位身家十亿美元以上的富豪,在香港、台湾和澳门还有94位,而美国仅有535位。
1997:H5N1传染人类1997: H5N1 Infects Humans
John Authers

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 明清家具将成秋拍亮点
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

金维刚表示:“2016年居民消费价格指数仅同比上涨2%,低于预期的预测指标。属于温和通胀范围,反映了物价水平得到有效控制并保持基本平稳。”

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 中美贸易战升级建材业吃亏
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

13. iPhone 提醒

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

adj. 笨拙的,尴尬的,(设计)别扭的
12. Scientists modify photosynthesis to boost crop yield

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

单词confident 联想记忆:
艾丽斯·斯瓦策尔(Alice Schwarzer)

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

However, five Beijing-based travel agents said they were still selling South Korea tours for March, as was China’s largest online travel company Ctrip. Representatives at the top three state-owned airline carriers in China told Bloomberg they had not received instructions to halt ticket sales to the country.
Rachel Bloom burst into tears as she won best lead in a comedy or musical TV show while Amazon show Mozart In The Jungle was another surprise victor at the awards show when it was named best TV comedy.

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 新华社:央企整体负债率稳中有降
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

其他入围者分别是:《失去信号:黑莓离奇崛起与惊人陨落背后不为人知的故事》(Losing the Signal: The Untold Story Behind the Extraordinary Rise and Spectacular Fall of Blackberry),作者杰基麦克尼什(Jacquie Mcnish)和肖恩缠尔科夫(Sean Silcoff)回顾了黑莓是怎样偏离了航向;《数字黄金:比特币背后不为人知的故事》(Digital Gold: The Untold Story of Bitcoin),作者纳塔涅尔波佩尔(Nathaniel Popper)审视了虚拟货币比特币的崛起;《音乐如何变免费:一整代人犯下同样罪行的后果》(How Music Got Free: What Happens When an Entire Generation Commits the Same Crime?),作者斯蒂芬威特(Stephen Witt)介绍了盗版和对等网络共享(P2P)扰乱唱片业的历史;《做不完的事:女人、男人、工作、家庭》(Un滻椀猀栀攀搀 Business: Women Men Work Family),作者安妮-玛丽斯劳特(Anne-Marie Slaughter)在书中讨论了实现性别平衡面临的挑战,以及《行为不端:解读行为经济学》(Misbehaving: The Making of Behavioural Economics),作者理查德泰勒(Richard Thaler)追踪了行为经济学的发展。
It seems safe to predict lots more noise and very little progress for the rest of 2017. And that will continue to be a damaging combination for business and the UK economy.
Bernard Baumohl, chief global economist of the Economic Outlook Group, said he is even more optimistic. "The next two years could be the best two we have seen in at least a decade," he said. "There is clearly a lot of evidence the economy is gaining a lot of momentum."
这难道不是我们所有人都想要的吗?唐·德雷珀(Don Draper)应该会理解的。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

可以这样说美国银行首席执行官布莱恩?莫尼汉这个人:他很会说话。在给股东的信中,莫尼汉特地感谢美国纳税人,正是由于他们,美国银行才获得了450亿美元的不良资产援助资金。他还说自己如今正在金融改革方面同“政策领导人”紧密合作。不过他是否能做好,比如转变美国银行的境遇,就是另外一回事了。虽然美国银行的确在去年12月偿还了援助资金,但是它仍然有数十亿美元的高风险住房与商用房房贷,这也是为什么它要在年度报告中花8000字来讨论风险了。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

去年世锦赛打破男子1500米自由泳世界纪录,孙杨就被认为是中国男子游泳在伦敦实现历史性突破的希望所在。即将开始的伦敦奥运会,孙杨将参加200米、400米和1500米自由泳三项.去年世锦赛孙杨在400米自由泳中不敌朴泰桓屈居亚军,因此他发誓要在伦敦复仇。相比而言,孙杨在1500米的夺金把握更大...
adj. 暂时的,临时的

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 北京市积分落户申报下周三启动
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Analysts believe the launch will help Apple to overcome its growth problem of the last two years. In markets such as America and Europe, where smartphone ownership is close to saturation and many customers are holding on to their existing handsets for longer, the best way to drive faster revenue growth is by charging more for each device, rather than simply relying on unit growth.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Brands with the most to make up for in 2015:Volkswagen, whose stale product line depressed sales by 11%, thereby delaying Ferdinand Piech’s plans for global supremacy, and Volvo, down 17%, which has yet to make any progress under its Chinese owner.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

在中国版推特新浪微博上,很多网民为男孩危急情况下的勇敢、淡定点赞。
Entrepreneur Pat Crowley, the hydrologist who invented the Chapul cricket protein bar, used Bigcommerce to validate early interest in his products and build the momentum to negotiate deals with health food stores and supermarkets. The team recently recommitted toBigcommerce, despite a compelling opportunity to switch to the Shopify platform for far less money. “We don’t think we will outgrow them anytime soon,” he said.
科学家表示,全球变暖加上强大的厄尔尼诺气候事件,令2015年成为自19世纪现代记录开始以来最热年份。科学家还警告,今年地球可能会更热。
protocol

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 陶瓷企业与供应商的“智斗”内幕
Review Article

Influenza neuraminidase: A druggable target for natural products

The total number of qualified applicants reached 31,220 in the first 24 hours, up from 25,000 over the same period last year, according to figures from offcn.com, an education organization that offers training for the civil servant exam.
[?'s?u?ieit]
本田已在美国召回了1000多万辆汽车,修复其安全气囊一项潜在的致命缺陷。这种气囊由日本供应商高田公司制造,其充气装置在发生车祸时会突然爆裂,溅出金属碎片伤及乘客。本田已确认有三起死亡和48起受伤事件与这一问题有关。
这张专辑等于是一次直截了当的暗示,提醒着我们,不论什么时候,只要霉女王想要,她就能拿回自己在流行音乐界的领先地位。
5. 生活就像一个茶几,上面摆满了杯具和餐具。(杯具是“悲剧”的同音词,餐具是“惨剧”的同音词。)

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 资本退潮 长租公寓重新洗牌
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Taylor Swift and Katy Perry opted for bedazzled5 dresses in very different styles. Taylor went for a more old Hollywood, glamorous Grecian style that exposed her back and statuesque6 figure, while Katy rocked a shorter, spunkier look that exposed a little of everything.
element

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

中国企业家王兴(音)通过聊天软件“微信”(WeChat)与身在美国加州的姐姐和澳大利亚的叔叔保持联系。这款聊天软件让人得以一瞥中国网络公司怎样参与全球竞争。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Call it the crisis of whiteness.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

内衣秀以马戏表演开始,包括杂技,吞剑和踩高跷。然后贾斯汀比伯,蕾哈娜和布鲁斯马斯登场。
谁被埋葬在这里?
3. Economy is already crashing, GDP will get even worse in 2014-2016
最后西蒙点评:“你们在唱的时候眼睛里透露出坚定,唱得相当投入,第一次我听到你们唱这首歌的时候我觉得很惊艳,而这一次提高了不少,更上了一个台阶。”

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
From the themed collection: 北京朝阳将建十座地区文化中心
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

The People’s Bank of China has long intervened in foreign-exchange markets to hedge against excessive volatility. Since August, however, such intervention has expanded from the domestic spot market, which covers daily transactions, to include the offshore renminbi market in Hong Kong, as well as both onshore and offshore futures markets, traders say.
neglect
'She enjoys it and we don't force her to do anything she doesn't want to do.'
China does not want to see a trade war between the US and China. That would not make our trade fairer and cause loss for the both sides.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

“The headwinds that Chinese banks face will last for a long time,” he said. “In addition to lower sources for profit, they will also have to prepare themselves for losses on bad loans.”
Elspeth Cheung, head of BrandZ valuation at Millward Brown, says: “The top 10 used to be dominated by consumer goods. This year, it’s technology.”

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 借口房贷新政 折定金赔违约金
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

James Bond Themes Honorable Mention: "We Have All The Time in the World" by Louis Armstrong
单词scroll 联想记忆:
quality
You see all kinds of grisly, hairy characters on the Tube but few commuters would've expected to see a pack of pandas on the platform.
It scares/intimidates people and they don't know better anyway.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

5) I take a gloomy view of things 0 1 2 3 4
IE’s online MBA consistently attracts high-calibre students. Half of IE’s alumni were senior managers when they enrolled, the highest proportion among ranked schools at that stage. Three years after graduation they were earning the highest average salary at $179,000, about $30,000 more than the next highest earners — alumni from Olin Graduate School of Business at Babson College.
布雷克·格里芬的高中样子和现在相差不大。只要在高中版的格里芬上加一些头发,再增大他的肌肉,就变成了如今的格里芬。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Ahh, the glamorous life of AT&T: best friends with Steve Jobs, exclusive rights to the iPhone (for now) and carrier of choice on the iPad. So why, with everything going for it, did the stock miss a huge rally? In the year ending April 1, Apple soared 109% and the S&P 500 rose 41%. AT&T? Down 2%. The problem is growth, or lack thereof: little in its saturated wireless business and a decline in landlines, which still accounts for 25% of sales. Unless its high-speed Internet business takes off or the iPad drives new wireless growth, the beatings by Wall Street will continue.
badminton;basketball;fencing;Judo;Ping Pang;taekwondo;Tennis;weightlifting;Wrestling;Volleyball;Boxing;Hocky.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

9)做得不错:毫无疑问,这有点陈词滥调的味道。有时,仅说一句“谢谢”还不够。人们想知道他们的工作完成得是否出色,也想知道为什么他们工作干的出色。毕竟,他们为项目流了太多的汗水,倾注了太多的心血。他们需要知道自己的工作很特别且是有意义的。
在岛上海边的总督大楼,数万名支持群众等待罗塞略在宣誓就职典礼后的到来,手握着伞挡住炽热阳光。
这名官员称,米特卜王子已于11月28日获释。米特卜王子在11月初以前一直掌管着颇有实权的国民警卫队。至少还有三名嫌疑犯也完成了和解协议。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

大小:6364平方英尺(约591平方米)
黑人小伙克里斯和白人女孩露丝交往到了见家长的一步。露丝邀请男友去北部父母家共度周末。女友的父母对自己甚是热情,起初,克里斯把这种过度热情解读为父母试图面对女儿跨种族爱情的紧张反应,但随后,一连串蛛丝马迹令人越来越不安,克里斯渐渐察觉,背后的真相远非自己所能想象的。
同样令人震惊的是百日咳的发病率上升了59%,而百日咳是一种半个世纪前的综合免疫接种计划没能彻底消灭的疾病。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: LED芯片行业大洗牌 将只剩5家企业
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

贾斯汀·比伯成全美音乐奖最大赢家

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

[ri'li:s]

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Paris (AFP) - Some 1,400 people living in France have either joined the jihadist cause in Syria and Iraq or are planning to do so, Prime Minister Manuel Valls said Monday.
据《外交政策》网站报道,在通往世界杯奖杯的漫漫征程中,比利时和乌拉圭是夺冠热门球队希望避开的两座冰山。在今年的世界杯赛场上,尽管比利时和乌拉圭都是不起眼的小角色,但它们有能力让比盲目自信的对手喝上一壶。虽然它们是历史上的小国,地缘政治上的出气筒,但很明显,他们在足球场上仍然极具竞争力。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

'It's been low for a while, says Lee (last year it was ranked 196 out of 200). 'What probably pushed it to the bottom is that several things got worse job prospects decreased, the average salary continued to fall, and work hours continued to rise. Those factors also make the job more stressful.'
5. Starbucks. Brand love: 26% / Social Business Index Rank: 26
Carve out a place at home that is your study space. If you've got a family around you, make sure everyone understands that when you're in that space, you're not to be interrupted unless the house is on fire.
No.2: Another Reason for Staying in Bed

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

卡梅隆·安东尼
chann管道+el表名词,“人或物”→航道

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Sinta Nuriyah carries forth her family’s campaign in Indonesia, holding interfaith events and establishing a network of progressive Islamic boarding schools for girls.
还有些人直接就玩消失了:

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

It’s wall-to-wall pure pop heaven, crackling with originality and dark humor, teeming with action sequences so perfectly timed and executed you almost want to run out of the theater on the spot so you can call a friend and rave about it — but you wouldn’t dare leave your seat because you wouldn’t want to miss a frame of this brilliant, pulse-quickening gem.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

The first chart shows the total incidence of banking, currency and debt default crises in emerging markets since the 1970s, set against the nominal federal funds rate. Mr Koepke gives this as evidence that high and rising rates typically precede periods of EM crisis.
许多人在学习小组中受益良多。你得有条有理地进行,不能拖延时间。你要将学习的内容彻底消化,并能够向别人复述出来。
明年就是这只会说话的萌熊诞生60周年了。为了纪念帕丁顿熊诞生60周年,曾执导2014年口碑和票房都大获成功的电影《帕丁顿熊》的保罗?金回归续集担任导演。在当前这个连儿童娱乐节目都充斥着黑暗和暴力的时代,我们比以往任何时候都需要这种安静地讲述英国普通人生活的片子。这部新电影的情节?事实上,没有太多情节:根据上部电影的结尾,帕丁顿熊现在和温莎花园的布朗一家舒适地生活在一起。他想从一个当地的书商那里给他的姨妈买一本立体书,但发现自己还差几英镑,于是他就穿上了自己的长筒雨靴和粗呢连帽外套,并找到了几份兼职工作——结果却发现这本书在书店被偷了!神秘的破案之旅(其实也没那么严重)就此开始。你在电影中还可以看到关于“橘子酱控”帕丁顿熊的更多笑话。该片将于11月10日在英国上映,11月23日在德国上映,11月30日在柬埔寨和马来西亚上映。(资料来源:欧映嘉纳)
Based on a new estimate provided by the government of Dubai, its visitor spending of $31.3 billion this year far exceeds London's estimated $19.8 billion, which comes second.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 整装市场下的卫浴行业新趋势
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Comic skit “Big City Small Life”(Wang Ning, Chang Yuan and Ailun)
说到这一点,你要注意的是,不要影响其他的人。没有人想每隔十分钟就听到你提问一次。如果你实在是不懂的话,可以在课后约上老师再讨论。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Tencent said in an email it has no current plans to find a profitable model for WeChat. An Internet conglomerate, Tencent is China's largest listed Internet company with a market capitalization of roughly $65 billion and has strong revenue streams from gaming, virtual products and advertising on other platforms.
第一种看法是,油价本质上具有周期性。下跌之后必然会回升。这道波谷越深,下一个山峰就越高。
1. Battle of the Sexes

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 地方定价项目再减30%
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

PRRI research director Daniel Cox said that some respondents - including 75 percent of non-white Protestants - believe extreme weather is both evidence of end times and the result of climate change.
Graduates in economics and finance still have great prospects for making big money, the National Business Daily reported, citing a new survey. The average monthly salary for graduates from five major Chinese universities in finance and economics stayed above 10,000 yuan.
活跃的ETF市场将取决于基于收费的分销网络的发展。富达国际(Fidelity International)亚太区董事总经理陶博宏(Mark Talbot)表示,分销基础设施正抑制零售需求。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

【中文译文】
从一个孩子的视角,讲述佛罗里达州一家汽车旅馆社区的生活。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

According to the announcement, the new administrative center in Tongzhou will put infrastructure upgrades and ecological improvement on top of the agenda. The municipal government hopes to improve public services in education, healthcare, cultural events and industries in the district.
Despite car and truck sales that motored past 16 million for the first time since 2007, recalls dominated the news for most of the year. General Motors GM 1.42% held center stage, dealing with cascading revelations about faulty ignition switches and recalling millions of vehicles. While GM opted for something approaching full disclosure of its missteps , publishing an report into company-wide fumbles, Japanese airbag maker Tanaka chose to stonewall. It left any remedies up to its beleaguered customers, notably Honda and Toyota. They are the ones who deal with the fallout of exploding safety devices that fatally fired shrapnel throughout the passenger compartment.
当然,这些新势力也可能引发反弹,使得指挥-控制的老派领导方式卷土重来。令人郁闷的是,主宰世界舞台的政治人物大多是老派的,而他们面临的领导力挑战——从英国退欧到朝鲜问题——尤为复杂。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Consoles: PlayStation 4
Get Out

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

“Where ETFs have grown — in the US and Europe — there is a big ecosystem of financial advisers,” he says. “You need a more advisory model. But until you see people paying for advice rather than paying for commissions, it is hard to see when it will take off.”
受到密切关注的财新(Caixin)采购经理人指数(PMI)系列调查显示,该指数在四个月来首次显示扩张趋势。这一结果表明,上个月中国经济活动出现了增长。
However, the economists polled expect slightly higher growth rates and substantially higher inflation over 2016.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Participants in the study were between the ages of 18 and 44 and were asked to run twice – with and without shoes. After completing their quick runs, researchers found that the heart rate and overall run speed of each participant had no effect on memory, but the presence of shoes or bare feet did. The researchers have hypothesized that the need to engage the mind while running barefoot to avoid pebbles or other impediments could have a positive impact on a person's ability to remember things. If you're an adventurous person, you might try taking a barefoot jog around the block before your next test or before you need to remember something important.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

如果美国汽车行业杂志《沃兹汽车》(Wardsauto)的专家最新编撰的最佳引擎榜单可作为一种指示,那么在当代轿车、卡车和跨界车的引擎盖下面正发生一场静悄悄的革命。涡轮增压、机械增压和柴油引擎——甚至还有一款电动发电机——主导了第20届年度十大最佳汽车引擎奖;根据《沃兹汽车》,这些奖项“表彰了杰出的动力系统成就、世界级技术以及那些帮助推动汽车销售的稀有发动机或者电力推进系统。”
During the RoboCup 2500 contestants from 40 countries competed in 15 competitions with various types of computerized soccer robots, healthcare robots, rescue robots and dance robots.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

因此,看看吧。我真诚地希望你们会喜欢它们,就像我在挑选和编辑它们时那样。
9. Meghalaya, India-"Meghalaya won't stay this quiet for long; go before thrill seekers storm the Khasi Hills," advises Lonely Planet. Pictured is Nohkalikai Falls, India's tallest plunge waterfall at 340 meters.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Beyoncé featuring Nicki Minaj “Flawless (Remix)” (Parkwood/Columbia)
弗兰西斯麦克多蒙德在这个黑色喜剧故事中扮演一位悲伤的母亲,展现了出色的核心表演。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Sarah O’Connor is employment correspondent
An escalating war on drugs in the Philippines has led to almost 1,800 deaths under new president Rodrigo Duterte, the country’s police chief has said.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

And regarding Ukraine, the Russian president again denied that there are Russian troops operating inside eastern Ukraine where a pro-Russian separatist movement is fighting Ukrainian government troops. But he said Moscow never denied that "certain people" were there carrying out tasks "in the military sphere." He said Russia plans no sanctions against Ukraine, but will not extend preferential trade to Kyiv.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

希拉里屹立不倒:希拉里·克林顿的个人履历中充满了第一:唯一一位成为美国参议员后来成为呼声很高的总统候选人后来又成为国务卿的第一夫人。现在,作为一名淡出公众视线的公民,她仍然是这个世界上最受关注和意见最受重视的女性之一。大家都打赌她会是2016年美国民主党角逐总统选举的候选人,并揣测她会是这个自由世界的下一任领袖。她并不试图平息这些议论,上个月她以估计每场20万美元的报酬进行巡回演讲,并据传签署了一份金额高达1,400万美元的售书协议。
While Switzerland’s University of St Gallen retains the top spot, French and British business schools, with 24 and 18 programmes respectively, are the backbone of the 2017 FT ranking of 95 programmes around the world. More than half of UK schools move up the ranking, compared with one in France. A third of British schools rise five places, in contrast to the two-thirds of French schools that drop five or more places.
slew是slow慢慢聚集的
Tiger got to hunt, bird got to fly;

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

这笔交易令17岁的达洛伊西奥成为百万富翁。他在12岁时自学编写软件程序,他将一边继续学业,一边参与雅虎伦敦办事处的工作。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

人命关天,安全至上。
[ni'glekt]
Whatever the underlying cause, last year’s extreme warmth in the West meant that Alaska, Arizona, California and Nevada all set temperature records. Some parts of California essentially had no winter last year, with temperatures sometimes running 10 to 15 degrees above normal for the season. The temperature in Anchorage, Alaska’s largest city, never fell below zero in 2014, the first time that has happened in 101 years of record-keeping for the city.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

No. This crisis hit Amsterdam in 1772, after a respected Dutch investment syndicate made a disastrous bet on shares of the British East India Company.
Meanwhile, celebrated American rapper Eminem proved to be the comeback king as he picked up the Best Hip Hop gong. The Lose Yourself hitmaker was up against the newer faces of hip hop, including Drake, Future, Kendrick Lamar and Post Malone.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

政治也对气候的认知有所影响,超过3/4的民主党人和六成独立派人士认为在过去几年中气候越来越极端,而不到半数共和党人认同这种转变。
The raised decoration shows a cartouche — an oval frame around Egyptian hieroglyphics indicating a royal name. Above the frame archaeologists could make out the symbol of an eye and that of a cobra.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: 房地产税法拟5年内提请审议
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

China’s foreign exchange reserves posted their third-largest monthly decline on record last month, central bank data showed yesterday, renewing worries about capital outflows after reserves had appeared to stabilise.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

该读数最后一次高于50是在2月份。对于该指数来说,是否高于50是区分制造业活动是扩张还是收缩的荣枯线。
在2007年,苹果公司发布了第一款iPhone手机:带有虚拟键盘的全触屏手机。对很多人来说,苹果取得了新突破,发明了新事物--他们制造了第一款触屏手机。但这种说法是错误的:苹果不是第一个制造触屏手机的公司,触屏也不是什么新发明。
谈到他想让他们的关系“正式化”的愿望,拉格菲尔德曾表示:“目前还没有人类和动物结婚的……我从未想过我会像这样爱上一只猫咪。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

You don't know how to fix the holes in our ozone layer. You don't know how to bring salmon back up a dead stream. You don't know how to bring back an animal now extinct.And you can't bring back forests that once grew where there is now desert. If you don't know how to fix it, please stop breaking it! 您不知道怎么去修补大气的臭氧空洞,您也不知道怎么去从死亡的河流中拯救鱼类,您更不知道如何把灭绝的动物复苏,您也不能把沙漠中从前完整的森林带回来。如果您不知道如何拯救,那么请您停止破坏吧!
荷兰危机牵涉到成熟的金融专业人士,那些惯于分析金融和经济趋势的人们。但是,他们过于看重个人经验。
普华永道中国内地及香港市场负责人林怡仲表示,市场的波动导致了新股审批的节奏的加紧,从而维持资本市场的稳定。
根据荷兰经济政策研究局(Netherlands Bureau for Economic Policy Analysis)发布的《世界贸易监测》(World Trade Monitor)报告,以美元计算,去年跨越国际边境的商品总价值下降了13.8%,是自2009年以来的首次萎缩。这一暴跌很大程度上源于中国和其他新兴经济体的放缓。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

大多数观察家认为去年五月首飞的单过道C919就是图中这架飞机。尽管这是一项突破性进展,但它并不能完全代表中国航空工业的发展。其他两个例子更有说服力。
Although it picked up a best editing prize from the LA Film Critics Association, it was ignored by their New York counterparts. Could its momentum be waning?

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

最佳录影带:Little Big Town《Tornado》
'But then it always challenges and nudges and says "well wait a minute".
In early November the government further tightened controls over outbound investment by requiring regulatory approval for some foreign acquisitions conducted through an offshore entity.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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这条推文也是今年人们“点赞最多”的推文,收获的赞达459万个。
李亦表示:“贫困阻碍了网民数量的进一步增加,使得网民数量占全部人口的比例只在50%左右。”

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